Promising Alzheimer's drug candidate prevents buildup of tau …
WEB22 hours ago · The drug, a peptide inhibitor called RI-AG03, was effective at preventing the buildup of tau proteins in both lab and fruit fly studies. The research, published in Alzheimer's & Dementia, was led ...
Dual-Targeting Drug Halts Tau Accumulation in Alzheimer’s
WEB13 hours ago · Summary: Scientists have developed a drug that targets both major aggregation-promoting sites of the Tau protein, a key player in Alzheimer’s disease. This peptide inhibitor, RI-AG03, effectively prevents Tau buildup in lab studies and fruit flies, offering hope for new Alzheimer’s treatments. Unlike …
Promising 'First' in Alzheimer's drug development | ScienceDaily
WEB14 hours ago · The drug, a peptide inhibitor called RI-AG03, was effective at preventing the build-up of Tau proteins in both lab and fruit fly studies. Skip to main content Your source for the latest research news
New Drug Candidate Works to Inhibit Both Tau Protein “Hotspots” …
WEB1 day ago · An international team of researchers has developed a promising new drug that works on both major Tau protein aggregation “hotspots,” a key driver of neurodegeneration including Alzheimer’s disease.The novel peptide inhibitor, RI-AG03, has demonstrated efficacy in preventing Tau aggregation in both laboratory and fruit fly studies, while showing no toxicity to cells.
Alzheimer’s breakthrough after drug treatment success
WEB1 day ago · News Science Alzheimer’s breakthrough after drug treatment success The study found that the medication, called RI-AG03, was effective at preventing the build-up of Tau proteins
Alzheimer’s Game Changer: Dual-Action Drug Attacks
WEB22 hours ago · The paper describes how RI-AG03 was first developed by Dr. Aggidis in the laboratory of the late Professor Allsop, using computational biology where it was tested in lab dishes. The brain of a 7-day-old fruit fly with Tau expressed in a neuronal circuit used by the fly in olfactory memory.
A novel peptide-based tau aggregation inhibitor as a potential ...
WEBRI-AG03 also rescues a biosensor cell line that stably expresses Tau repeat domains with the P301S mutation fused to Cer/Clo and rescues aggregation-dependent phenotypes in vivo, suppressing neurodegeneration and extending lifespan. Collectively our data describe several properties and attributes of RI-AG03 that make it a promising disease ...
Promising ‘first’ in Alzheimer’s drug develop | EurekAlert!
WEB22 hours ago · Testing RI-AG03 The paper describes how RI-AG03 was first developed by Dr Aggidis, in the laboratory of the late Prof David Allsop, using computational biology at Lancaster University, where it ...
'One-of-a-kind' new Alzheimer's drug RI-AG03 shows promise
WEB22 hours ago · Abnormal clumps of tau are called neurofibrillary tangles (NFTs) — they are a hallmark of Alzheimer’s, a neurodegenerative condition that affects an estimated 7 million Americans. Now, an ...
Promising ‘first’ in Alzheimer’s drug development
WEBTesting RI-AG03 To test its effectiveness in cells within a living organism, researchers at the University of Southampton then gave the drug to fruit flies that had pathogenic Tau. These fruit fly models of Alzheimer's Disease were generated by Dr Shreyasi Chatterjee who is a Senior Lecturer at Nottingham Trent University.
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